Author

Aisling S. Morrin

Cardiff University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Gareth Wyn JonesiD· 4 shared Simon A. JonesiD· 4 shared Ana Cardus FiguerasiD· 3 shared Carol GuyiD· 3 shared David Gregory HilliD· 3 shared Ernest H ChoyiD· 3 shared Federica Monaco· 3 shared Sandra DimonteiD· 3 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

Gareth Wyn JonesORCID

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Author profile →

4 papers

Recent·Most cited

Inflammatory arthritis disrupts ocular immune privilege by compromising blood-retinal barrier integrity and promoting uveitogenic T cell recruitment

Simon Eastham, Amy Ward, Chloe Moscrop, David Gregory Hill, Aisling S. Morrin, Sandra Dimonte, Alison Young, Simon A. Jones, Jian Liu, Andrew D. Dick, David A. Copland, Lindsay B. Nicholson, Gareth Wyn Jones

This study shows inflammatory arthritis disrupts the blood-retinal barrier and promotes T cell recruitment to the eye, increasing susceptibility to uveitis without causing overt ocular disease.

bioRxiv · Jul 17, 2026 · PreprintImmunology

Discrete cytokine signaling networks instruct distinctsynovial pathotypes in inflammatory arthritis

Alicia Derrac Soria, David Gregory Hill, Stuart T. O. Hughes, Reuben N. Scott, Ana Cardus Figueras, Sandra Dimonte, Daniela O. Costa, Ngoc‐Nga Vinh, Federica Monaco, Robert L. Jenkins, Xiao Liu, Myles Lewis, Jason P. Twohig, Carol Guy, Aisling S. Morrin, , Simon A. Jones

The paper identifies distinct cytokine signaling networks in mouse models of arthritis that mirror human RA synovial pathotypes, revealing molecular mechanisms underlying disease heterogeneity.

bioRxiv · Nov 1, 2025 · PreprintPathology

Interleukin-6 elevates thrombosis via pro-coagulant phospholipids from platelet 12-lipoxygenase in rheumatoid arthritis.

Daniela O. Costa, Stuart T.O Hughes, Robert L. Jenkins, Ana Cardus Figueras, Majd B. Protty, Victoria J. Tyrrell, Ali A Hajeyah, Gareth Wyn Jones, James J Burston, Beth Morgan, Federica Monaco, David Gregory Hill, Aisling S. Morrin, Carol Guy, Alice Bacon, , Valerie B. O’Donnell

This study identifies IL-6's role in elevating thrombosis in RA via platelet 12-lipoxygenase-generated pro-coagulant phospholipids.

bioRxiv · Mar 26, 2025 · PreprintPharmacology & Toxicology

IL-6 and IL-27 negatively regulate CRTAM-expressing CD4+ T-cells associated with lymphoid-driven synovitis.

Alicia Derrac Soria, Myles Lewis, Xiao Liu, Jason P. Twohig, Federica Monaco, Sandra Dimonte, Ana Cardus Figueras, Aisling S. Morrin, Carol Guy, Benjamin C. Cossins, Robert A. Benson, Robert Andrews, Barbara Szomolay, Ernest H Choy, Paul Garside, , Simon A. Jones

The paper identifies CRTAM-expressing CD4+ T-cells in lymphoid-driven synovitis and shows that IL-6 and IL-27 inhibit their activation through STAT3 and ZEB1.

bioRxiv · Sep 3, 2024 · PreprintImmunology