Author

Daniela O. Costa

Cardiff UniversityORCID 0000-0001-8821-5898Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Aisling S. Morrin· 2 shared Ana Cardus FiguerasiD· 2 shared Carol GuyiD· 2 shared David Gregory HilliD· 2 shared Ernest ChoyiD· 2 shared Federica Monaco· 2 shared Gareth Wyn JonesiD· 2 shared Peter Vincent JenkinsiD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPathology

Aisling S. Morrin

Mutual co-authors in cluster

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3 papers

Recent·Most cited

PathologybioRxivPreprintNov 1, 2025

Discrete cytokine signaling networks instruct distinctsynovial pathotypes in inflammatory arthritis

Alicia Derrac Soria, David Gregory Hill, Stuart T. O. Hughes…·Simon A. Jones

The paper identifies distinct cytokine signaling networks in mouse models of arthritis that mirror human RA synovial pathotypes, revealing molecular mechanisms underlying disease heterogeneity.

DOI 10.1101/2025.11.01.686006

mousebulk RNA-seq

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Pharmacology & ToxicologyJournal of Blood MedicinePeer-reviewedNov 1, 2025

Pro-coagulant lipids in physiological ratios found in the activated platelet membrane do not impact clot structure or fibrinolysis in purified assays.

Bethan Morgan, Laura E Farleigh Smith, Daniela O. Costa…·Valerie B. O’Donnell

The paper tests the effect of pro-coagulant lipids on clot structure and fibrinolysis using physiological ratios and finds no significant impact.

DOI 10.2147/jbm.s527558

statistical model

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Pharmacology & ToxicologybioRxivPreprintMar 26, 2025

Interleukin-6 elevates thrombosis via pro-coagulant phospholipids from platelet 12-lipoxygenase in rheumatoid arthritis.

Daniela O. Costa, Stuart T.O Hughes, Robert L. Jenkins…·Valerie B. O’Donnell

This study identifies IL-6's role in elevating thrombosis in RA via platelet 12-lipoxygenase-generated pro-coagulant phospholipids.

3 citations

mousehuman

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