Author

Ernest Choy

Cardiff UniversityORCID 0000-0003-4459-8609Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aisling S. Morrin· 3 shared Ana Cardus FiguerasiD· 3 shared Carol GuyiD· 3 shared Federica Monaco· 3 shared Gareth Wyn JonesiD· 3 shared Simon A. JonesiD· 3 shared Alicia Derrac SoriaiD· 2 shared Barbara SzomolayiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPathology

Aisling S. Morrin

Mutual co-authors in cluster

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3 papers

Recent·Most cited

PathologybioRxivPreprintNov 1, 2025

Discrete cytokine signaling networks instruct distinctsynovial pathotypes in inflammatory arthritis

Alicia Derrac Soria, David Gregory Hill, Stuart T. O. Hughes…·Simon A. Jones

The paper identifies distinct cytokine signaling networks in mouse models of arthritis that mirror human RA synovial pathotypes, revealing molecular mechanisms underlying disease heterogeneity.

DOI 10.1101/2025.11.01.686006

mousebulk RNA-seq

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintMar 26, 2025

Interleukin-6 elevates thrombosis via pro-coagulant phospholipids from platelet 12-lipoxygenase in rheumatoid arthritis.

Daniela O. Costa, Stuart T.O Hughes, Robert L. Jenkins…·Valerie B. O’Donnell

This study identifies IL-6's role in elevating thrombosis in RA via platelet 12-lipoxygenase-generated pro-coagulant phospholipids.

3 citations

mousehuman

𝕏 PostBluesky

ImmunologybioRxivPreprintSep 3, 2024

IL-6 and IL-27 negatively regulate CRTAM-expressing CD4+ T-cells associated with lymphoid-driven synovitis.

Alicia Derrac Soria, Myles Lewis, Xiao Liu…·Simon A. Jones

The paper identifies CRTAM-expressing CD4+ T-cells in lymphoid-driven synovitis and shows that IL-6 and IL-27 inhibit their activation through STAT3 and ZEB1.

DOI 10.1101/2024.09.03.610972

humanmouse

𝕏 PostBluesky