obABPP-HT*: A Precision-Engineered Activity Proteomics Pipeline for the Streamlined Discovery of Deubiquitinase Inhibitors
Hannah B. L. Jones, Simeon D. Draganov, Sofia Schönbauer Huamán, Peter A. C. Wing, Chuong Nguyen, Zhu Liang, Julia Dörner, Jasper Lithgow, Emma J. Murphy, Alice Beard, Andrea Pierangelini, Jack W. Houghton, Mackenzie E. Robert, Sarah E. Flannery, Anthony Tumber, , Adán Pinto-Fernández
This paper introduces a high-throughput activity proteomics pipeline for discovering deubiquitinase inhibitors, identifying potent and selective inhibitors with minimal optimization.
bioRxiv · May 27, 2025 · PreprintBiochemistry