Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor culture
Hariam Raji, Federico Bertoli, Maria Jose Perez J., Alicia Lam, Laura A. Volpicelli‐Daley, Michela Deleidi
This paper develops a method to generate human midbrain organoids enriched in SNpc-like dopaminergic neurons using WNT modulation and bioreactor culture, showing improved functionality and vulnerability to Parkinson's disease pathology.
Molecular Psychiatry · Jun 17, 2026Peer-reviewedNeuroscience