Indra Heckenbach

The paper identifies and characterizes SA-βGal-high naive T cells that exhibit senescent-like features but retain proliferative capacity and cytotoxic properties, linking lysosomal-autophagic dysfunction to immune aging and inflammaging.

This study shows that mitochondrial stress in human microglia disrupts communication with neurons and promotes senescence, contributing to neurodegenerative processes.

This study shows that sleep disruption in mice increases cellular senescence in visceral adipose tissue, leading to oxidative stress and DNA damage, which may accelerate aging and age-related diseases.

This study shows CD38 loss increases ovarian NAD+ levels and fecundity in young mice but not in older mice.

The paper identifies SIRT5 and KAT2A as regulators of histone malonylation, showing its role in ribosomal gene expression and age-related changes in mouse brains.

The paper identifies mt-ELP3 as a mitochondrial tRNA modifying enzyme that protects mt-tRNAs from degradation and enhances mitochondrial translation and OXPHOS complex expression.