Morten Scheibye‐Knudsen

The paper develops an EEG-based brain age clock using machine learning to predict chronological age and assess brain aging, showing a decrease in brain age with intervention.

This study uses single-cell transcriptomics to analyze immune aging, finding that acute COVID and HIV+ART both increase naive CD8 T cell transcriptomic age.

DORA AI Scientist automates scientific research tasks and report generation using multi-agent AI systems and LLMs, reducing manuscript preparation time and enabling more focus on discovery.

This study shows that mitochondrial stress in human microglia disrupts communication with neurons and promotes senescence, contributing to neurodegenerative processes.

This study shows that sleep disruption in mice increases cellular senescence in visceral adipose tissue, leading to oxidative stress and DNA damage, which may accelerate aging and age-related diseases.

This study shows CD38 loss increases ovarian NAD+ levels and fecundity in young mice but not in older mice.

The paper identifies SIRT5 and KAT2A as regulators of histone malonylation, showing its role in ribosomal gene expression and age-related changes in mouse brains.

The paper identifies mt-ELP3 as a mitochondrial tRNA modifying enzyme that protects mt-tRNAs from degradation and enhances mitochondrial translation and OXPHOS complex expression.

The paper identifies atracurium as an FDA-approved compound that extends lifespan and healthspan in C. elegans by activating the FOXO/DAF-16 longevity pathway through neuromuscular acetylcholine receptor inhibition.