Stefanie Kalb

The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence

This study shows that mitochondrial stress in human microglia disrupts communication with neurons and promotes senescence, contributing to neurodegenerative processes.

Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids

This study shows that PITRM1 deficiency in human cerebral organoids leads to Alzheimer's-like pathology, including protein aggregates and tau pathology, while 2D cultures do not show these features.