MitoSAM-dependent lipoylation controls postnatal heart development via metabolic remodeling
Anastasia Rumyantseva, Alissa Wilhalm, William Carter, Trevor S. Tippetts, Marco F. Moedas, Florian A. Rosenberger, David Moore, Ákos Végvári, Yvonne Hinze, Linden Muellner-Wong, David Alsina, Rolf Wibom, Rainah Winston, Thomas P. Mathews, Lars H. Lund, , Anna Wredenberg
This study shows that mitoSAM-dependent lipoylation is essential for postnatal heart development by enabling metabolic remodeling from glycolysis to oxidative phosphorylation.
bioRxiv · Apr 20, 2026 · PreprintBiochemistry