Joanna Rorbach

ATP Synthase Activity Couples Bioenergetics to Mitochondrial Translation

This study shows mitochondrial translation is sensitive to ATP synthase activity, with matrix GTP availability identified as a key constraint.

Non-coding exon splicing orchestrates tissue-specific expression of two functionally distinct mitochondrial isoforms of Mitofusin 2

The paper identifies a tissue-specific mitochondrial isoform of MFN2 generated by non-coding exon splicing and shows its distinct functional role in lipid trafficking.

The mitochondrial methylation potential gates mitoribosome assembly

The paper shows that mitochondrial SAM is essential for processing mitochondrial ribosomal RNA precursors and ribosome assembly.

Multi-layered dosage compensation of the avian Z chromosome

The paper examines dosage compensation mechanisms on the avian Z chromosome in female, male, and intersex chickens, revealing transcriptional and translational strategies similar to mammalian X-chromosome compensation.

Structural basis of streptomycin off-target binding to human mitoribosome

This paper reports the 2.23-[A] resolution structure of the human mitoribosomal small subunit bound to streptomycin, revealing new insights into its off-target interactions.

YbeY is required for ribosome small subunit assembly and tRNA processing in human mitochondria

This study identifies YbeY as essential for mitochondrial ribosome small subunit assembly and tRNA processing, showing its dual role in coupling these processes.

Differential processing and localization of human Nocturnin controls metabolism of mRNA and nicotinamide dinucleotide metabolites

This study shows that human Nocturnin regulates mRNA levels and NADP(H) cofactors based on its subcellular localization.