The pyruvate branch point controls lymphoid cancer cell dissemination
Hamidullah Khan, Steven V John, Sushmita Roy, Mohd Farhan, Nguyet Minh Hoang, Patrick Buethe, Aman Prasad, Aman Nihal, David T. Yang, Lixin Rui, Jing Fan, Stefan M. Schieke
This study identifies the pyruvate branch point as a metabolic checkpoint controlling lymphoid cancer cell migration and dissemination via mROS/HIF-1a signaling.
bioRxiv · Mar 18, 2026 · PreprintCancer Biology