Laura Guiguettaz

The rapid delivery of RNase H variants reveals distinct classes of RNA:DNA hybrids

The paper develops iCoRD to rapidly deliver RNase H1 in live cells and shows it affects specific RNA:DNA hybrids and replication fork stability.

Viral Infections Drive Functional Remodeling of Ribosome-Associated Proteins

The paper develops an improved method to capture ribosome-associated proteins and shows viral infections remodel these proteins in a virus-specific manner, with functional implications for viral propagation.

Rapid delivery of RNase H1 enables replication fork progression under stress independently of R-loop resolution

This study shows that rapid delivery of RNase H1 rescues replication fork progression under stress without affecting R-loops.

Unveiling novel conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling.

This study uses ribosome profiling to identify conserved HIV-1 alternative open reading frames (ARFs) that encode T cell antigens, revealing new targets for vaccination.

Translation-dependent and independent mRNA decay occur through mutually exclusive pathways that are defined by ribosome density during T Cell activation.

The paper shows that mRNA decay during T cell activation occurs through translation-dependent and independent pathways, with ribosome density determining the pathway used.