Valeria Poli

This study identifies TGS1 as a methyltransferase that modifies mRNAs encoding mitochondrial proteins in AML, promoting oxidative phosphorylation and cell survival, and shows its potential as a therapeutic target.

This study shows LSD induces adaptive stress transcriptional programs in the prefrontal cortex of mice, aligning with hormetic adaptation rather than chronic stress.

This study shows that LSD induces gene expression patterns opposing aging and neurodegeneration in the brain, suggesting potential therapeutic effects through transcriptional reversal.

This paper shows that combining three KRAS signaling pathway inhibitors effectively regresses pancreatic tumors and prevents resistance in preclinical models.

This study identifies lactate as a tumor-secreted metabolite that inhibits B cell chemotaxis and TLS formation in TNBC by disrupting mitochondrial metabolism.

The paper shows that cell cycle-specific long noncoding RNAs regulate the establishment and recycling of the acetylated histone H2A.Z epigenetic mark.