Neuropilin-1 is a co-receptor for NGF and TrkA-evoked pain
Chloe J. Peach, Raquel Tonello, Elisa Damo, Kimberly Gómez, Aida Calderón‐Rivera, Renato Bruni, Harsh Bansia, Laura Maile, Ana-Maria Manu, Hyunggu Hahn, Alex Rojas Bie Thomsen, Brian L. Schmidt, Steve Davidson, Amédée des Georges, Rajesh Khanna, Nigel W. Bunnett
This paper identifies NRP1 as a co-receptor for NGF and TrkA pain signaling and shows that targeting NRP1 or GIPC1 can reduce chronic pain without opioid use.
bioRxiv · Dec 6, 2023 · PreprintNeuroscience