Raquel Tonello

Endocytosis and Compartmentalized Intracellular Signaling of the Prostaglandin Receptor EP4 Mediate Pain

This study shows that EP4 receptor internalization and compartmentalized signaling in DRG nociceptors mediate PGE2-induced pain, suggesting new strategies for inflammatory pain management.

The contribution of endocytic mediators to itch transmission

This study investigates the role of endocytic mediators in itch transmission, finding that disrupting AAK1 and Dnm1/Dnm3 reduces scratching behavior without affecting motor function or anxiety.

Targeting Synaptic Vesicle Endocytosis in Nociceptors Provides Sustained Pain Relief

This study identifies synaptic vesicle endocytosis in nociceptors as a driver of chronic pain and shows that targeting it with CRISPR/dCas9-R via lipid nanoparticles provides long-lasting pain relief without affecting acute pain responses.

Targeting the Schwann Cell EP2/cAMP Nanodomain to Block Pain but not Inflammation

The paper identifies a druggable EP2 receptor in Schwann cells that encodes PG-mediated persistent inflammatory pain without affecting protective inflammation.

Characterization and targeting of the endosomal signaling of the gastrin releasing peptide receptor in pruritus.

This study investigates GRPR endosomal signaling in pruritus and shows that endosomal targeting of GRPR antagonists is more effective in blocking itch sensation.

Neuropilin-1 is a co-receptor for NGF and TrkA-evoked pain

This paper identifies NRP1 as a co-receptor for NGF and TrkA pain signaling and shows that targeting NRP1 or GIPC1 can reduce chronic pain without opioid use.

Satellite glial GPR37L1 regulates maresin and potassium channel signaling for pain control

This study identifies GPR37L1 in satellite glial cells as a regulator of pain control through interactions with potassium channels and maresin 1, showing its role in neuropathic pain resolution.

Resolvin D3 controls mouse and human nociceptive functions and preclinical progression of psoriasis

This study shows that resolvin D3 reduces skin inflammation and itch in psoriasis models by inhibiting nociceptive functions in both mice and human neurons.