Small Molecule Disruption of a Protein Disulfide Isomerase-Containing Multi-Protein Complex Causes Broad Cancer Selective Metabolic Collapse and Tumor Inhibition in vivo
Anuradha F. Lingappa, Suguna Mallesh, Maya Michon, D. SHIVARUDRASWAMY, Jim Jung‐Ching Lin, M. Dharma Prasad, Debendranath Dey, Dennis Solas, Vishwanath R. Lingappa, Andreas Mueller-Schiffmann, David Andrews, Carsten Korth, Stevan Pecic
PAV-620 and PAV-805 disrupt PDI-containing complexes, causing metabolic collapse and tumor inhibition in cancer models without toxicity to healthy cells.
bioRxiv · Feb 28, 2025 · PreprintBiochemistry