Author

M. Dharma Prasad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Assay:proteomics· 1

Frequent Co-Authors

Anuradha F. LingappaiD· 2 shared Carsten KorthiD· 2 shared Debendranath DeyiD· 2 shared Dennis Solas· 2 shared Maya MichoniD· 2 shared Suguna Mallesh· 2 shared Vishwanath R. LingappaiD· 2 shared Amanda Macieik· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersBiochemistry

Anuradha F. LingappaORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Small Molecule Disruption of a Protein Disulfide Isomerase-Containing Multi-Protein Complex Causes Broad Cancer Selective Metabolic Collapse and Tumor Inhibition in vivo

Anuradha F. Lingappa, Suguna Mallesh, Maya Michon, D. SHIVARUDRASWAMY, Jim Jung‐Ching Lin, M. Dharma Prasad, Debendranath Dey, Dennis Solas, Vishwanath R. Lingappa, Andreas Mueller-Schiffmann, David Andrews, Carsten Korth, Stevan Pecic

PAV-620 and PAV-805 disrupt PDI-containing complexes, causing metabolic collapse and tumor inhibition in cancer models without toxicity to healthy cells.

bioRxiv · Feb 28, 2025 · PreprintBiochemistry

Protein Assembly Modulation: A New Approach to ALS Therapeutics

Shao Feng Yu, Kumar Paulvannan, Dennis Solas, Anuradha F. Lingappa, Ana Raquel Moreira, Shriya Sahu, Maya Michon, Amanda Macieik, Danielle Goldsmith, Nicholas DeYarman, Suguna Mallesh, M. Dharma Prasad, Claudia Maios, Kai Ruan, Giulio Srubek Tomassy, , Jeffrey Rosenfeld

This paper introduces a new drug-like small molecule series targeting PDI in a multi-protein complex for ALS treatment, showing activity in cellular and animal models.

Journal of Experimental Neurology · Jan 1, 2024Peer-reviewedNeuroscience