Inhibition of histone lysine demethylase restores learning and memory in aged mice
Shail Ratna Bhatt, Lachlan Ford MacBean, Enikö A. Kramár, Leticia Pérez‐Sisqués, Phillip Smethurst, Josephine Louise Robb, Neeru Jindal, Tracy L. Fetterly, Andrew Graham, Marcelo A. Wood, Sébastien Gillotin, Karl-Peter Giese, M. Albert Basson
This study shows that inhibiting LSD1, a histone demethylase, restores learning and memory in aged mice by reversing age-related defects in H3K4me3 dynamics and synaptic plasticity.
bioRxiv · Dec 23, 2025 · PreprintNeuroscience