Python metabolomics uncovers a conserved postprandial metabolite and gut-brain feeding pathway
Shuke Xiao, Mengjie Wang, Thomas G. Martin, Barry Scott, Xing Fang, Xinming Liu, Yongjie Yang, Sipei Fu, Steven D. Truong, Jack F. Gugel, Gregory Maas, Marcus Mullen, Jennifer Hampton Hill, Veronica L. Li, Andrew L. Markhard, , Jonathan Z. Long
The paper identifies a conserved postprandial metabolite, pTOS, that links nutrient intake to energy balance through a gut-brain pathway in pythons and mice, with potential relevance to humans.
Nature Metabolism · Mar 19, 2026Peer-reviewedPhysiology