Cancer-driven neutrophil priming couples systemic epithelial regenerative programs with pre-metastatic niche formation
Nicolas Rabas, Victoria Louise Bridgeman, Anisha Ramessur, Constandina Pospori, Marc Hennequart, Felipe Silva Rodrigues, Ana Farias, Rute M. M. Ferreira, Konstantinos Axarlis, Olamide Nduka, Probir Chakravarty, Nathalie Michelle Legrave, Izadora Liranço Furlani, R. Charles Coombes, James MacRae, Ilaria Malanchi
This study identifies neutrophil-driven systemic conditioning that links inflammation, tissue regeneration, and metastasis, with UPP1 as a key factor in neutrophil priming.
bioRxiv · Oct 20, 2025 · PreprintCancer Biology