Ilaria Malanchi

The paper identifies differences in liver and lung metastatic niches in breast cancer, showing liver promotes metastasis while lungs inhibit it, and highlights BMP2-producing endothelial cells in the liver as key players.

The paper shows that IFNg induces both stemness and differentiation in AML cells, leading to heterogeneous responses that affect leukemia growth and regeneration.

The paper identifies a sex-specific neural memory mechanism in the pancreas that influences epithelial plasticity and tissue resilience after injury.

This study shows that type I interferons from respiratory viral infections reduce lung metastasis by altering the lung environment and impairing tumor cell growth.

This study shows that integrin conformation-dependent neutrophil slowing in pre-metastatic lungs obstructs capillaries and may contribute to immunosuppression in breast cancer.

This paper develops an injectable hydrogel platform with poly(orthoester) microparticles for long-term, zero-order drug release, demonstrating in vitro and in vivo efficacy for up to 12 months.

The paper shows that inhibiting neutrophil degranulation with Nexinhib20 delays radiation-induced pulmonary fibrosis without affecting cancer radiotherapy efficacy.

This study identifies neutrophil-driven systemic conditioning that links inflammation, tissue regeneration, and metastasis, with UPP1 as a key factor in neutrophil priming.

This study shows liver metastases reduce checkpoint inhibitor efficacy by increasing splenic granulopoiesis and S100A9hi neutrophils, which suppress T-cell responses, and demonstrates that targeting S100A9 restores efficacy.

The paper introduces BOCTAG, a method to label glycoproteins in specific cell types within mixed cultures, enabling analysis of cell-specific glycosylation.