Human NMDAR autoantibodies disrupt excitatory-inhibitory balance leading to hippocampal network hypersynchrony
Mihai Ceangă, Vahid Rahmati, Holger Haselmann, Lars Schmidl, Daniel Hunter, Anna-Katherina Brauer, Sabine Liebscher, Jakob Kreye, Harald Prüß, Laurent Groc, Stefan Hallermann, Josep O. Dalmau, Alessandro Ori, Manfred Heckmann, Christian Geis
This study shows that NMDAR autoantibodies disrupt the excitatory-inhibitory balance in the hippocampus, leading to network hypersynchrony and symptoms resembling schizophrenia.
Cell Reports · Sep 27, 2023Peer-reviewedNeuroscience