Stefan Hallermann

The paper identifies cerebellar pathology as a conserved yet distinct feature in severe SMA, showing divergent therapeutic outcomes with SMN-restoring therapies.

The paper identifies ethanol-enhanced presynaptic shunting inhibition at the first central auditory synapse as a mechanism for alcohol-induced auditory dysfunction.

The paper develops a multi-behavioral phenotyping approach in larval zebrafish to identify neurotoxic chemicals, finding chlorophene disrupts habituation via GABAARs and resembles Kv7 activator effects.

The paper shows that chronic inactivity does not broadly affect action potentials in neocortical neurons but does in hippocampal neurons under specific conditions.

This study investigates how LGI1 autoantibodies enhance synaptic transmission by reducing Kv1 channel density and broadening presynaptic action potentials.

This study shows that LGI1-reactive monoclonal antibodies cause seizures in rats, with molecular and electrophysiological evidence of epileptogenesis.

The paper measures the Ca2+ sensitivity of Syt1-triggered release in neocortical synapses and finds it has high affinity and cooperativity.

This study identifies Rab3 as a mediator of cAMP-induced presynaptic plasticity and shows its necessity for olfactory learning in Drosophila.

This study shows ketamine increases presynaptic glutamate release in cerebellar synapses by enhancing calcium influx and vesicle readiness, suggesting a direct presynaptic mechanism for its antidepressant effects.

This study shows that LTP at layer 5 pyramidal neurons increases synaptic strength by increasing the number of fully-primed, slowly-recovering vesicles.

This study shows that NMDAR autoantibodies disrupt the excitatory-inhibitory balance in the hippocampus, leading to network hypersynchrony and symptoms resembling schizophrenia.

This study develops NMDA-receptor-Fc-fusion constructs that neutralize anti-NMDA receptor antibodies and inhibit their effects on neurons.

This study shows that neuronal activity drives the translocation of LGI1 and ADAM23 to the synaptic cleft, adjusting excitatory neurotransmission based on activity history.

The paper investigates Ca2+-dependence of synaptic vesicle recruitment, priming, and fusion at cerebellar mossy fiber synapses, revealing distinct Ca2+ sensors for each step.

The paper reports direct recordings of presynaptic action potentials in neocortical boutons, showing differential broadening in excitatory and inhibitory neurons.

This study shows that Piccolo knockout rats exhibit anatomical and behavioral features similar to Pontocerebellar Hypoplasia type 3, supporting a causal link between Piccolo function and PCH3.

The paper identifies biophysical gradients in cerebellar granule cells that enable Fourier-like transformation of mossy fiber inputs and enhance spike-timing precision.

This study shows HCN channels modulate action potential velocity and fidelity in central axons through cAMP and neuromodulators, with implications for energy consumption and temporal delays.

This study identifies Complexin as a conserved vesicular protein that interacts with Bruchpilot's C-terminus to tether synaptic vesicles to the active zone cytomatrix in Drosophila and mouse synapses.