The conserved N-terminal SANT1-binding domain (SBD) of EZH2 Regulates PRC2 Activity
Agata L. Patriotis, Yadira M. Soto‐Feliciano, Douglas Barrows, Laiba F Khan, Marylène Leboeuf, Peder J. Lund, Matthew R. Marunde, Annaelle Djomo, Michael‐Christopher Keogh, Thomas S. Carroll, Benjamin A. Garcia, Alexey A. Soshnev, C. David Allis
This study investigates how the conserved SBD of EZH2 regulates PRC2 activity, showing its necessity for histone methylation and cancer cell proliferation.
Genes & Development · Feb 9, 2026Peer-reviewedGenetics