Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution
Alex A. Pollen, Aparna Bhaduri, Madeline G. Andrews, Tomasz Jan Nowakowski, Olivia S. Meyerson, Mohammed A. Mostajo-Radji, Elizabeth Di Lullo, Beatriz Alvarado, Melanie A. Bedolli, Max L. Dougherty, Ian T. Fiddes, Zev N. Kronenberg, Joe Shuga, Anne A. Leyrat, Jay A. A. West, , Arnold R. Kriegstein
The paper uses chimpanzee cerebral organoids to identify human-specific genes in cortical development and finds increased PI3K/AKT/mTOR activation in human outer radial glia.
Cell · Feb 1, 2019Peer-reviewedDevelopmental Biology