Jay A. A. West

The paper introduces unCTC, an R package for unbiased identification and characterization of CTCs from scRNA-Seq data, validated on breast CTCs.

This study uses ResolveOME to analyze genomic and transcriptomic data in individual cells, revealing mutations and gene expression changes linked to drug resistance and oncogenic mechanisms.

The paper introduces PTA for single-cell DNA sequencing and SCAN2 to detect somatic SNVs and indels in single neurons, finding age-related increases in both with indels having greater functional impact.

The paper uses chimpanzee cerebral organoids to identify human-specific genes in cortical development and finds increased PI3K/AKT/mTOR activation in human outer radial glia.

C1 CAGE detects transcription start sites and enhancer activity in lung cancer cells, revealing subpopulations with distinct responses to TGF-β and enhancer RNA dynamics.

The paper investigates how miRNA-mRNA networks regulate cell-type-specific transcriptomes during human brain development using AGO2-HITS-CLIP, single-cell profiling, and bipartite network analysis.