Martijn van de Bunt

The paper uses targeted chromatin interaction profiling to identify causal genes at type 2 diabetes GWAS loci with higher sensitivity and resolution than genome-wide methods.

This study identifies thyroid hormone receptor THRB as a key regulator of hepatocyte maturation from human PSCs, showing that T3 treatment enhances gene expression and epigenetic features of mature hepatocytes.

The paper investigates how genetic variants affect gene expression in human pancreatic islets and identifies candidate genes linked to type 2 diabetes.

This paper identifies 56 new type 2 diabetes loci in 433,540 East Asian individuals through a meta-analysis of GWAS data.

This study evaluates multi-SNP transcriptome-wide association models for gene expression in human tissues and their ability to identify causal genes for metabolites.

The paper shows that a loss-of-function variant in ZnT8 improves insulin secretion and protects against type 2 diabetes by enhancing glucose responsiveness and proinsulin conversion.

The paper identifies genetic variants and transcripts associated with glycemic traits by analyzing exome-array data from 144,600 individuals, highlighting tissue-specific roles in glucose regulation.

The paper integrates genetic, genomic, and functional data to identify convergent biological pathways in type 2 diabetes, revealing enriched functional connectivity among causal genes.

The paper integrates chromatin accessibility and DNA methylation data from human pancreatic islets to refine regulatory mechanisms at Type 2 Diabetes susceptibility loci.

This study examines the electrophysiological and secretory properties of human β-cell lines EndoC-βH1 and -βH2, finding they closely resemble primary human β-cells in insulin secretion and ion channel behavior.