Mackenzie C. Gamble

This study shows that chronic fentanyl-xylazine co-exposure causes sex-dependent changes in sleep, respiratory function, and molecular markers in mice.

This study maps morphine-induced brain activity in male and female mice over time, revealing sex-specific and time-dependent patterns of c-Fos expression.

This study identifies sex-specific transcriptional changes in the SCN of rats during oxycodone withdrawal and abstinence, linking these changes to addiction-related behaviors.

SleepInvestigatoR streamlines sleep analysis in rodents by automating calculations and visualization of sleep metrics from scored files.

This study examines how neonatal fentanyl exposure in mice affects sleep and circadian rhythms during adolescence, finding altered sleep-wake patterns.

This study identifies keratinocytes and PDGF-B/PDGFRβ signaling as key mediators of peripheral opioid tolerance in mice, showing that PDGF-B release from keratinocytes drives tolerance through activation of PDGFRβ in sensory neurons.

This study examines how 2-AG affects sleep and circadian rhythms in male and female mice during fentanyl withdrawal, finding sex-specific effects on sleep disruption.

The paper characterizes striatal projection neuron heterogeneity in mice using single-nuclei multi-omics and spatial mapping, revealing distinct subtypes with unique receptor expression and disease risk contributions.

This study examines how fentanyl affects sleep architecture and how the circadian factor NPAS2 influences these changes during withdrawal in male mice.

This study characterizes BF vGluT2 neurons, showing they project to arousal-related and aversive stimulus areas and induce avoidance behavior.

This study identifies BF parvalbumin neurons as a key component of the brain circuitry mediating brief arousals from sleep in response to internal and external stimuli.