GLIS3 Marks a Neural-like Progenitor Cell State that Drives Metastasis in Pancreatic Ductal Adenocarcinoma
Dennis H. Gong, Jimmy A. Guo, Jennifer Su, Sueda Cetinkaya, Connor J. Hennessey, Patrick Z. Yu, Ananya D. Jambhale, Peter L. Wang, Nicholas J Caldwell, Ashley Lam, Junning Wang, Carina Shiau, Kevin S. Kapner, Julien Dilly, Laleh Abbassi, , William L. Hwang
This study identifies Glis3 as a key transcription factor driving metastasis in PDAC by promoting a neural-like progenitor cell state.
Cell Reports · Apr 27, 2026Peer-reviewedCancer Biology