The Pdgfd-Pdgfrb axis orchestrates tumor-nerve crosstalk in pancreatic cancer
Peter L. Wang, Nicole A. Lester, Ella N. Perrault, Jennifer Su, Dennis H. Gong, Carina Shiau, Jingyi Cao, Phuong Trang Nguyen, Jung Woo Bae, Deniz Olgun, Hannah I. Hoffman, Ashley Lam, Jean Huang-Gao, Saifur Rahaman, Jimmy A. Guo, , William L. Hwang
This study identifies Pdgfd-Pdgfrb signaling as a driver of perineural invasion in pancreatic cancer by promoting cancer cell invasiveness and nerve engagement.
bioRxiv · Aug 26, 2025 · PreprintCancer Biology