Microbiota- and diet-specific T cells become Tregs by default
Jeffrey J. Bunker, Jamie Blum, Xiandong Meng, Eugenell Mae Lopez, Allison M. Weakley, Ashley V. Cabrera, Steven Kyle Higginbottom, Ryan Kong, E.A. Schulman, Elizabeth S. Sattely, James J. Moon, Michael Andrew Fischbach
The paper shows that T cells specific for microbiota and diet antigens predominantly become regulatory T cells (iTregs) in the gut, with effector responses emerging only under specific inflammatory and genetic conditions.
bioRxiv · Aug 27, 2026 · PreprintImmunology