Author

Fleur Leguay

de Duve Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Nick van GasteliD· 3 shared Ayşegül Erdem· 2 shared Nithya BalasundaramiD· 2 shared Andrew A. LaneiD· 1 shared Azeem ShardaiD· 1 shared Charles VidoudeziD· 1 shared David T. ScaddeniD· 1 shared Didier VertommeniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

Nick van GastelORCID

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3 papers

Recent·Most cited

Protein S-acylation dynamics provide metabolic plasticity to acute myeloid leukemia cells

Nithya Balasundaram, Ayşegül Erdem, Azeem Sharda, Veerle W. Daniëls, Phillip L. Chea, Fleur Leguay, YOUZHONG LIU, Mark A. Keibler, Charles Vidoudez, Andrew A. Lane, Didier Vertommen, Hans Casteur, Michaël R. Laurent, Sunia A. Trauger, Gregory N Stephanopoulos, , Nick van Gastel

This study identifies a unique metabolic plasticity mechanism in AML cells through protein S-acylation, which is inhibited by TOFA and a glutaminase inhibitor combination.

bioRxiv · Mar 3, 2026 · PreprintCancer Biology

The EAAT1 aspartate/glutamate transporter is dispensable for acute myeloid leukemia cell growth and response to therapy

Hernán A. Tirado, Nithya Balasundaram, Jean Jacobs, Fleur Leguay, Lotfi Laaouimir, Nick van Gastel

This study investigates the role of EAAT1 in AML cell growth and therapy response, finding that EAAT1 inhibition does not impair AML growth or chemosensitivity.

PLoS ONE · Feb 24, 2026Peer-reviewedCancer Biology

Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival

Ayşegül Erdem, Séléna Kaye, Francesco Caligiore, Manuel Johanns, Fleur Leguay, Jan Jacob Schuringa, Keisuke Ito, Guido T. Bommer, Nick van Gastel

This study shows that LDHA is essential for maintaining NAD+/NADH balance in AML cells, and its inhibition leads to cell death, suggesting it as a therapeutic target.

Cancer & Metabolism · May 19, 2025Peer-reviewedCancer Biology