Systematic identification of regulators of antibody-drug conjugate toxicity using CRISPR-Cas9 screens
C. K. Tsui, R. M. Barfield, C. R. Fischer, D. W. Morgens, A. Li, B. A. H. Smith, C. R. Bertozzi, D. Rabuka, M. C. Bassik
This study uses CRISPR-Cas9 screens to identify genes regulating antibody-drug conjugate (ADC) toxicity, revealing endolysosomal trafficking regulators and mechanisms of ADC resistance.
bioRxiv · Mar 3, 2019 · PreprintCancer Biology