C. K. Tsui

CRISPR screens and lectin microarrays identify novel high mannose N-glycan regulators

The paper uses CRISPR screens and lectin microarrays to identify TM9SF3 and the CCC complex as novel regulators of high mannose N-glycan synthesis.

The microenvironment dictates glycocalyx construction and immune surveillance

This study shows that the physical properties of the microenvironment influence glycocalyx composition and immune surveillance in vitro using physiologically relevant models.

Lipid homeostasis is essential for a maximal ER stress response

This study identifies let-767 as a gene critical for lipid and ER protein homeostasis, showing that lipid metabolism influences the ER stress response.

Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin health and lifespan.

The paper identifies BET-1 as a regulator of actin health and lifespan through genetic screens in human fibroblasts and C. elegans.

Measuring expression heterogeneity of single-cell cytoskeletal protein complexes

The paper introduces a method to measure single-cell cytoskeletal protein complex expression heterogeneity and finds some cells upregulate other cytoskeletal complexes in response to stress.

Systematic identification of regulators of antibody-drug conjugate toxicity using CRISPR-Cas9 screens

This study uses CRISPR-Cas9 screens to identify genes regulating antibody-drug conjugate (ADC) toxicity, revealing endolysosomal trafficking regulators and mechanisms of ADC resistance.