Author

D. W. Morgens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

M. C. Bassik· 3 shared A. Colville· 1 shared A. Goshayeshi· 1 shared A. J. Mathiowetz· 1 shared A. Li· 1 shared A. Rivera-Madera· 1 shared A. S. Souza· 1 shared B. A. Glaunsinger· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersCell Biology

M. C. Bassik

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Author profile →

4 papers

Recent·Most cited

From enhancers to genome conformation: complex transcriptional control underlies expression of a single herpesviral gene

D. W. Morgens, L. Gulyas, A. Rivera-Madera, A. S. Souza, B. A. Glaunsinger

The paper identifies cis-regulatory elements controlling ORF68 expression in KSHV and shows how their 3D genomic positioning changes during the viral lifecycle.

bioRxiv · Jul 8, 2023 · PreprintMicrobiology

Parallel CRISPR-Cas9 screens reveal mechanisms of PLIN2 and lipid droplet regulation

M. A. Roberts, K. K. Deol, M. Lange, D. E. Leto, A. J. Mathiowetz, J. Stevenson, S. H. Hashemi, D. W. Morgens, E. Easter, K. Heydari, M. A. Nalls, M. C. Bassik, M. Kampmann, R. R. Kopito, F. Faghri, J. A. Olzmann

The paper uses CRISPR-Cas9 screens to identify genes regulating PLIN2 and lipid droplet abundance, revealing new mechanisms and creating a resource for lipid metabolism research.

bioRxiv · Aug 27, 2022 · PreprintCell Biology

Death-seq identifies regulators of cell death and senolytic therapies

A. Colville, J.-Y. Liu, S. Thomas, H. D. Ishak, R. Zhou, J. D. D. Klein, D. W. Morgens, A. Goshayeshi, J. S. Salvi, D. Yao, K. Spees, M. C. Bassik, T. A. Rando

Death-seq identifies enhancers of cell death and senolytic therapies through a CRISPR screen, revealing synergistic combinations that clear senescent cells without thrombocytopenia.

bioRxiv · Apr 1, 2022Cell Biology

Systematic identification of regulators of antibody-drug conjugate toxicity using CRISPR-Cas9 screens

C. K. Tsui, R. M. Barfield, C. R. Fischer, D. W. Morgens, A. Li, B. A. H. Smith, C. R. Bertozzi, D. Rabuka, M. C. Bassik

This study uses CRISPR-Cas9 screens to identify genes regulating antibody-drug conjugate (ADC) toxicity, revealing endolysosomal trafficking regulators and mechanisms of ADC resistance.

bioRxiv · Mar 3, 2019 · PreprintCancer Biology