F. Hopkins

Antibiotic treatment does not abrogate protection against Mycobacterium tuberculosis reinfection

This study shows antibiotic treatment after primary Mtb infection reduces lung inflammation but does not eliminate protection against reinfection in macaques.

Multiplexed strain phenotyping defines consequences of genetic diversity in Mycobacterium tuberculosis for infection and vaccination outcomes

This study uses molecular barcoding to analyze genetic diversity in Mtb strains, showing L2 strains have distinct growth dynamics and resist BCG vaccination.

The structure of a native orthobunyavirus ribonucleoprotein reveals a key role for viral RNA in maintaining its helical architecture

This paper determines the 3D structure of a native bunyavirus ribonucleoprotein (RNP) using cryo-EM, revealing a helical architecture stabilized by RNA rather than longitudinal contacts between nucleoprotein monomers.

Spontaneous control of SIV replication does not prevent immune dysregulation and bacterial dissemination in animals co-infected with M. tuberculosis

This study shows that SIV+ animals, regardless of viral control, have higher Mtb burden and dysregulated immune responses, leading to increased bacterial dissemination.

SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis

This study compares the effects of SIV infection and CD4 depletion on Mtb reactivation in a macaque model, finding that SIV promotes more severe granuloma dissemination and bacterial burden.