Author

B. C. Berk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. G. Hsu· 2 shared C. L. Chavez· 2 shared M. Sowden· 2 shared A. Catic· 1 shared B. Saez· 1 shared C. T. Hill· 1 shared C. Yan· 1 shared C. Zhang· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

C. G. Hsu

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Author profile →

3 papers

Recent·Most cited

Pnpt1 mediates NLRP3 inflammasome activation by MAVS and metabolic reprogramming in macrophages

C. G. Hsu, W. Li, M. Sowden, C. L. Chavez, B. C. Berk

This study shows that Pnpt1 mediates NLRP3 inflammasome activation in macrophages through MAVS and metabolic reprogramming, enhancing IL-1β and IL-18 secretion in sepsis models.

bioRxiv · May 7, 2022Immunology

The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis

C. G. Hsu, C. L. Chavez, C. Zhang, M. Sowden, C. Yan, B. C. Berk

This study shows that 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis in models of acute lung injury and sepsis.

bioRxiv · Feb 1, 2022Immunology

Cyclophilin A regulates protein phase separation and mitigates haematopoietic stem cell aging

L. Maneix, P. Iakova, S. E. Moree, J. C. K. King, D. B. Sykes, C. T. Hill, B. Saez, E. Spooner, D. S. Krause, E. Sahin, B. C. Berk, D. T. Scadden, A. Catic

This study identifies Cyclophilin A as a key regulator of protein phase separation and shows its role in mitigating haematopoietic stem cell aging.

bioRxiv · Feb 24, 2021Cell Biology