Author

D. T. Scadden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Research Focus:differential expression· 5 Research Focus:cell-cell communication· 4 Approach:experimental assay· 4 Approach:statistical model· 4 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3

Frequent Co-Authors

D. B. Sykes· 4 shared Y. Kfoury· 4 shared A. O. Subtelny· 2 shared C.-L. Wu· 2 shared N. Baryawno· 2 shared P. J. Saylor· 2 shared P. V. Kharchenko· 2 shared S. Mei· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

D. B. Sykes

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Cell of origin epigenetic priming determines susceptibility to Tet2 mutation

G. Schiroli, V. K. Kartha, F. M. Duarte, T. A. Kristiansen, C. Mayerhofer, R. Shrestha, A. Earl, Y. Hu, T. Tay, C. Rhee, J. Buenrostro, D. T. Scadden

The paper shows that the epigenetic state of the cell of origin influences susceptibility to Tet2 mutation, with Sox4 promoting dedifferentiation and increased clonal output in hematopoietic stem cells.

bioRxiv · Sep 4, 2023 · PreprintCancer Biology

Myelodysplastic syndromes disable human CD271+VCAM1+CD146+ niches supporting normal hematopoietic stem/progenitor cells

Y. kawano, H. Kawano, D. Ghoneim, T. J. Fountaine, D. K. Byun, M. W. LaMere, J. H. Mendler, T.-C. Ho, N. A. Salama, J. R. Myers, S. E. Hussein, B. J. Frisch, J. M. Ashton, M. Azadniv, J. L. Liesveld, , L. M. Calvi

The paper identifies a specific MSC subset supporting normal HSPCs and shows its dysfunction in MDS.

bioRxiv · Apr 9, 2023 · PreprintCancer Biology

A new transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma

A. M. Alchahin, S. Mei, I. Tsea, T. Hirz, Y. Kfoury, D. Dahl, C.-L. Wu, A. O. Subtelny, S. Wu, D. T. Scadden, J. H. Shin, P. J. Saylor, D. B. Sykes, P. V. Kharchenko, N. Baryawno

The paper identifies a transcriptional signature in primary ccRCC tumors that predicts metastatic potential and patient survival.

bioRxiv · Jun 28, 2022Cancer Biology

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironment

T. Hirz, S. Mei, H. Sarkar, Y. Kfoury, S. Wu, B. M. Verhoeven, A. O. Subtelny, D. V. Zlatev, M. W. Wszolek, K. Salari, E. Murray, F. Chen, E. Z. Macosko, C.-L. Wu, D. T. Scadden, , D. B. Sykes

This study uses single-cell and spatial transcriptomic analyses to characterize the prostate tumor microenvironment, revealing immune suppression and high angiogenic activity.

bioRxiv · Mar 18, 2022 · PreprintCancer Biology

tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche

Y. Kfoury, F. Ji, M. Mazzola, D. B. Sykes, A. K. Scherer, A. Anselmo, Y. Akiyama, F. Mercier, N. Severe, K. D. Kokkaliaris, T. Brouse, J. Seidl, A. Papzian, P. Ivanov, M. K. Mansour, , D. T. Scadden

The paper shows that stress-induced extracellular vesicles transfer tiRNAs to hematopoietic progenitors, enhancing myeloid recovery and survival.

bioRxiv · Apr 13, 2021Cell Biology

Cyclophilin A regulates protein phase separation and mitigates haematopoietic stem cell aging

L. Maneix, P. Iakova, S. E. Moree, J. C. K. King, D. B. Sykes, C. T. Hill, B. Saez, E. Spooner, D. S. Krause, E. Sahin, B. C. Berk, D. T. Scadden, A. Catic

This study identifies Cyclophilin A as a key regulator of protein phase separation and shows its role in mitigating haematopoietic stem cell aging.

bioRxiv · Feb 24, 2021Cell Biology