Author

B. Krichel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Organism:virus· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Uetrecht· 3 shared K. Lorenzen· 2 shared S. Falke· 2 shared A. Haenle· 1 shared A. Peck· 1 shared A. Tolstikova· 1 shared B. Escudero-Perez· 1 shared B. Franca· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBiophysics

C. Uetrecht

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Author profile →

4 papers

Recent·Most cited

The kinetics of SARS-CoV-2 nsp7-11 polyprotein processing and impact on complexation with nsp16

K. Schamoni-Kast, B. Krichel, T. Damjanovic, T. Kierspel, S. Toker, C. Uetrecht

The paper quantifies the kinetics of SARS-CoV-2 polyprotein processing and its impact on RTC complex formation using native MS.

bioRxiv · Jan 6, 2024 · PreprintBiophysics

Inhibition of SARS-CoV-2 main protease by allosteric drug-binding

S. Guenther, P. Y. A. Reinke, Y. Fernandez-Garcia, J. Lieske, T. J. Lane, H. Ginn, F. Koua, C. Ehrt, W. Ewert, D. Oberthuer, O. Yefanov, S. Meier, K. Lorenzen, B. Krichel, J. Kopicki, , Schwi

The paper identifies 37 compounds binding to SARS-CoV-2 main protease through X-ray crystallography, with five non-peptidic compounds showing antiviral activity in cell-based assays.

bioRxiv · Nov 12, 2020Biophysics

Hallmarks of Alpha- and Betacoronavirus non-structural protein 7+8 complexes

B. Krichel, G. Bylapudi, C. Schmidt, C. Blanchet, R. Schubert, L. Brings, M. Koehler, R. Zenobi, D. Svergun, K. Lorenzen, R. Madhugiri, J. Ziebuhr, C. Uetrecht

This study determines the stoichiometry and topology of nsp7+8 complexes from seven coronaviruses using mass spectrometry and biophysical techniques, revealing three clustering groups with distinct assembly patterns.

bioRxiv · Sep 30, 2020Biophysics

Processing of the SARS-CoV pp1a/ab nsp7-10 region

B. Krichel, S. Falke, R. Hilgenfeld, L. Redecke, C. Uetrecht

The paper uses native mass spectrometry to analyze SARS-CoV polyprotein processing, revealing cleavage order and protein interactions in the nsp7-10 region.

bioRxiv · Dec 4, 2019Biophysics