Author

A. A. Ordonez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

S. K. Jain· 5 shared W. Bishai· 3 shared C. K. Bullen· 2 shared M. Klunk· 2 shared M. L. Turner· 2 shared O. Komm· 2 shared S. Krug· 2 shared A. F. Villabona-Rueda· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

S. K. Jain

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Dynamic single-cell RNA sequencing reveals BCG vaccination curtails SARS-CoV-2 induced disease severity and lung inflammation

A. K. Singh, R. Wang, K. A. Lombardo, M. Praharaj, C. K. Bullen, P. Um, S. Davis, O. Komm, P. B. Illei, A. A. Ordonez, M. Bahr, J. Huang, A. Gupta, K. J. Psoter, S. K. Jain, , W. Bishai

This study uses single-cell RNA sequencing to show BCG vaccination reduces SARS-CoV-2 lung inflammation and disease severity by enhancing antibody production and altering immune cell transcriptional profiles.

bioRxiv · Mar 15, 2022 · PreprintImmunology

Adjunctive inhibition of the integrated stress response pathway accelerates bacterial clearance in a mouse model of tuberculosis

S. Krug, P. Prasad, S. Xiao, S. Lun, C. A. Ruiz-Bedoya, M. Klunk, A. A. Ordonez, S. K. Jain, G. Srikrishna, I. Kramnik, W. Bishai

This study shows that inhibiting the Integrated Stress Response (ISR) pathway alongside standard TB antibiotics reduces bacterial loads and accelerates sterilization in a mouse model of tuberculosis.

bioRxiv · Dec 31, 2021 · PreprintMicrobiology

Host regulator PARP1 contributes to sex differences and immune responses in a mouse model of tuberculosis

S. Krug, A. A. Ordonez, M. Klunk, B. G. Kang, S. K. Jain, T. M. Dawson, V. L. Dawson, W. Bishai

This study identifies PARP1 as a key regulator of sex differences and immune responses in a mouse model of tuberculosis, showing it enhances early proinflammatory responses in males but impairs containment in females.

bioRxiv · Apr 21, 2021 · PreprintImmunology

Sulforaphane exhibits in vitro and in vivo antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses

A. A. Ordonez, C. K. Bullen, A. F. Villabona-Rueda, E. A. Thompson, M. L. Turner, S. L. Davis, O. Komm, J. D. Powell, F. R. D'Alessio, R. H. Yolken, S. K. Jain, L. Jones-Brando

This study shows sulforaphane inhibits SARS-CoV-2 and HCoV-OC43 replication in vitro and reduces viral load and lung injury in mice.

bioRxiv · Mar 25, 2021Microbiology

A chemiluminescent protease probe for rapid, sensitive, and inexpensive detection of live Mycobacterium tuberculosis

B. M. Babin, G. Fernandez-Cuervo, J. Sheng, O. Green, A. A. Ordonez, M. L. Turner, L. J. Keller, S. K. Jain, D. Shabat, M. Bogyo

A chemiluminescent probe detects live Mycobacterium tuberculosis with high sensitivity and speed, enabling improved TB diagnostics and drug resistance monitoring.

bioRxiv · Sep 14, 2020Microbiology