J. St-Germain

Adenomatous polyposis coli (APC) regulates internalization and signaling of the chemorepellent receptor, Roundabout (ROBO) 1

This study identifies APC's role in SLIT2-induced ROBO1 endocytosis and its impact on cell morphology.

Recruitment of FBXO22 for Targeted Degradation of NSD2

This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

This study identifies mitochondrial calcium utilization as a metabolic requirement of venetoclax-resistant acute myeloid leukemia stem cells and shows that targeting mitochondrial calcium uptake can eradicate these cells.

PRMT1 is a critical dependency in clear cell renal cell carcinoma through its role in post-transcriptional regulation of DNA damage response genes

Functional characterization of a PHF8 processed pseudogene in the mouse genome

The paper identifies a functional PHF8 pseudogene in mice that produces a cytoplasmic protein with distinct molecular functions compared to the parental Phf8 protein.

Fatty Acid Synthase inhibitor TVB-3166 prevents S-acylation of the Spike protein of human coronaviruses.

This study shows that TVB-3166 inhibits S-acylation of coronavirus Spike proteins, reducing viral spread and improving survival in mice.

Nucleotide binding, evolutionary insights and interaction partners of the pseudokinase Unc-51-like kinase 4

This study presents the structure of ULK4-ATPγS complex, identifies disease mutations affecting ATP binding, and reveals ULK4's interaction partners and evolutionary adaptations.