Author

B. S. Klein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:human· 2

Frequent Co-Authors

H. E. Dobson· 3 shared M. Wuethrich· 3 shared C. Ledesma Taira· 2 shared G. C. Kujoth· 2 shared L. Dos Santos Dias· 2 shared A. J. Crossen· 1 shared A. Xu· 1 shared B. Kingstad Bakke· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersImmunology

H. E. Dobson

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Author profile →

5 papers

Recent·Most cited

Single Cell Transcriptomes, Lineage, and Differentiation of Functional Airway Microfold Cells

M. V. Surve, B. Lin, J. L. Reedy, A. J. Crossen, A. Xu, B. S. Klein, J. M. Vyas, J. Rajagopal

This study identifies and characterizes airway Microfold (M) cells using single-cell transcriptomics, revealing their lineage, differentiation pathways, and functional role in antigen sampling via CR2-dependent endocytosis.

bioRxiv · Aug 6, 2023Cell Biology

Novel populations of CD4+ T cells associated with vaccine efficacy

T. Woodring, C. N. Dewey, L. Dos Santos Dias, X. He, H. E. Dobson, M. Wuethrich, b. s. klein

The paper identifies novel CD4+ T cell populations associated with protective immunity by comparing single-cell transcriptomes of vaccinated mice challenged with a fungal pathogen.

bioRxiv · Jun 23, 2022 · PreprintImmunology

Combination adjuvants enhance recombinant protein vaccine protection against fungal infection

M. Wuethrich, H. E. Dobson, C. Ledesma Taira, U. J. Okaa, N. Petrovsky, B. S. Klein

This study shows that combining adjuvants with a fungal recombinant protein vaccine enhances protection against Blastomyces dermatitidis infection by inducing specific T cell responses.

bioRxiv · Mar 11, 2021Immunology

Structural basis of Blastomyces Endoglucanase-2adjuvancy in anti-fungal and -viral immunity

L. Dos Santos Dias, H. E. Dobson, B. Kingstad Bakke, G. C. Kujoth, J. Huang, E. M. Kohn, C. Ledesma Taira, H. Wang, N. T. Supekar, P. Azadi, l. Li, M. Suresh, b. s. klein, M. Wuethrich

This paper identifies Bl-Eng2 as an adjuvant that enhances cell-mediated immunity against fungal and viral infections through structural and mechanistic insights.

bioRxiv · Jun 24, 2020 · PreprintImmunology

Club cell TRPV4 as a damage sensor driving lung allergic inflammation

D. L. Wiesner, R. M. Merkhofer, C. L. Ober, G. C. Kujoth, J. E. Gern, R. Brockman Schneider, M. D. Evans, D. J. Jackson, T. F. Warner, N. Jarjour, S. J. Esnault, M. B. Feldman, M. J. Freeman, H. Mou, J. Vyas, B. S. Klein

The paper identifies TRPV4 in club cells as a sensor for junction damage that drives lung allergic inflammation through calcium and calcineurin signaling.

bioRxiv · Sep 19, 2019Immunology