T. A. Zangle

Tracking of Lineage Mass via Quantitative Phase Imaging and Confinement in Low Refractive Index Microwells

This paper introduces a platform combining quantitative phase imaging and microwell confinement to improve lineage tracking by measuring cell mass.

LVING Reveals the Intracellular Structure of Cell Growth

LVING quantifies intracellular growth and degradation by measuring cell mass and transport velocity, revealing structural changes in cell states and drug effects.

Voltage-dependent volume regulation controls epithelial cell extrusion and morphology

The paper shows that cell shrinkage via voltage and water regulation determines which epithelial cells are extruded in crowded conditions.

Multiparametric quantitative phase imaging for real-time, single cell, drug screening in breast cancer

This study uses multiparametric quantitative phase imaging to assess drug response in breast cancer cells, revealing single-cell heterogeneity and resistance dynamics.

Laterally transferred macrophage mitochondria acts as a signaling source promoting cancer cell proliferation

The paper shows that dysfunctional macrophage mitochondria transferred to cancer cells promote proliferation via ROS-induced ERK signaling.

Quantitative Phase Velocimetry for Label-Free Measurement of Intracellular Mass Transport Velocity

This paper introduces quantitative phase velocimetry (QPV) to measure intracellular mass transport velocity without labels, enabling comparison of nuclear and cytoplasmic diffusivity.

Bidirectional interconversion between mutually exclusive tumorigenic and drug-tolerant melanoma cell phenotypes

This study identifies bidirectional interconversion between tumorigenic and drug-tolerant melanoma cell states through BRN2 expression, revealing distinct molecular programs and therapeutic implications.