Author

B. E. Welm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Bioengineering· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:whole-exome sequencing· 2

Frequent Co-Authors

K. P. Guillen· 3 shared M. T. Lewis· 3 shared A. L. Welm· 2 shared C.-H. Yang· 2 shared E. Cortes-Sanchez· 2 shared J. Gertz· 2 shared J. H. Chuang· 2 shared J. M. Vahrenkamp· 2 shared

Activity by Year

2018-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

K. P. Guillen

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Multiparametric quantitative phase imaging for real-time, single cell, drug screening in breast cancer

E. R. Polanco, T. E. Moustafa, A. Butterfield, S. D. Scherer, E. Cortes-Sanchez, T. Bodily, B. T. Spike, B. E. Welm, P. S. Bernard, T. A. Zangle

This study uses multiparametric quantitative phase imaging to assess drug response in breast cancer cells, revealing single-cell heterogeneity and resistance dynamics.

bioRxiv · Nov 26, 2021Bioengineering

PDXNet Portal: Patient-Derived Xenograft model, data, workflow, and tool discovery

S. Koc, M. W. Lloyd, J. Grover, S. Seepo, S. Lakshmi Subramanian, M. Ray, C. Frech, J. DiGiovanna, P. Webster, S. Neuhauser, A. Srivastava, X. Yi Woo, B. J. Sanderson, B. White, P. Lott, , J. H. Chuang

The paper introduces the PDXNet Portal, a centralized resource for PDX models and data, offering analysis workflows and facilitating cancer research collaboration.

bioRxiv · Oct 15, 2021Cancer Biology

A Network Approach to Identify Biomarkers of Differential Chemotherapy Response Using Patient-Derived Xenografts of Triple-Negative Breast Cancer

V. Petrosyan, L. E. Dobrolecki, L. Thistlethwaite, A. N. Lewis, C. Sallas, R. Rajaram, J. T. Lei, M. J. Ellis, K. Osborne, M. Rimawi, A. Pavlick, M. Shafaee, H. Dowst, A. B. Saltzman, A. Malovannaya, , M. T. Lewis

This paper identifies biomarkers of differential chemotherapy response in TNBC using a network-based approach and validates them in PDX models and clinical datasets.

bioRxiv · Aug 20, 2021 · PreprintCancer Biology

A breast cancer patient-derived xenograft and organoid platform for drug discovery and precision oncology

K. P. Guillen, M. Fujita, A. J. Butterfield, S. D. Scherer, M. H. Bailey, Z. Chu, Y. S. DeRose, L. Zhao, E. Cortes-Sanchez, C.-H. Yang, J. Toner, G. Wang, Y. Qiao, X. Huang, J. A. Greenland, , A. L. Welm

The paper develops patient-derived xenografts and organoids for breast cancer to enable drug screening and precision oncology, showing efficacy of an FDA-approved drug in a clinical case.

bioRxiv · Feb 28, 2021 · PreprintCancer Biology

STAT3 and GR cooperate to drive basal-like triple negative breast cancer gene expression and proliferation.

M. E. Conway, J. M. McDaniel, J. M. Graham, K. P. Guillen, P. G. Oliver, S. L. Parker, P. Yue, J. Turkson, D. J. Buchsbaum, B. E. Welm, R. M. Myers, K. E. Varley

This study identifies GR and STAT3 as cooperative drivers of basal-like triple negative breast cancer gene expression and shows that their inhibition synergistically reduces cell proliferation.

bioRxiv · Aug 9, 2019Cancer Biology

Clinical and genomic crosstalk between glucocorticoid receptor and estrogen receptor α in endometrial cancer

J. M. Vahrenkamp, C.-H. Yang, A. C. Rodriguez, A. Almomen, K. Berrett, A. N. Trujillo, K. P. Guillen, B. E. Welm, E. A. Jarboe, M. M. Janat-Amsbury, J. Gertz

The paper investigates the interaction between glucocorticoid receptor (GR) and estrogen receptor α (ER) in endometrial cancer, finding that GR expression correlates with poor prognosis and that their combined activity alters gene expression and genomic binding.

bioRxiv · Mar 7, 2018Cancer Biology