B. Traenkle

Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells

This study develops human SIRPα nanobodies for both functional modulation of myeloid cells and in vivo imaging of tumor infiltration.

A novel PNGase Rc for improved protein N-deglycosylation in bioanalytics and HDX-MS epitope mapping under challenging conditions

A nanobody-based toolset to monitor and modify the mitochondrial GTPase Miro1

This study develops Miro1-specific nanobodies as tools for monitoring and modifying Miro1 function in cells, with applications in imaging and targeted degradation.

A broadly neutralizing biparatopic Nanobody protects mice from lethal challenge with SARS-CoV-2 variants of concern

This study identifies a biparatopic nanobody that protects mice from lethal SARS-CoV-2 infection and reduces viral load and inflammation.

Single-domain antibodies for targeting, detection and in vivo imaging of human CD4+ cells

This study develops single-domain antibodies to target and image human CD4+ cells in vivo, demonstrating their utility in immunotherapy monitoring.

NeutrobodyPlex - Nanobodies to monitor a SARS-CoV-2 neutralizing immune response

The paper develops NeutrobodyPlex, a multiplex assay using bivalent nanobodies to analyze neutralizing antibodies against SARS-CoV-2 in patient sera.

A novel epitope tagging system to visualize and monitor antigens in live cells with chromobodies

This paper introduces a PepTag/PepCB system for real-time visualization and quantification of antigens in live cells using fluorescently labeled chromobodies.