Author

P. D. Kaiser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 3 Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:cell type annotation· 6 Assay:proteomics· 6 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Research Focus:protein folding & dynamics· 3

Frequent Co-Authors

U. Rothbauer· 10 shared B. Traenkle· 7 shared T. R. Wagner· 7 shared A. Zeck· 5 shared M. Gramlich· 5 shared S. Nueske· 5 shared A. Scholz· 4 shared D. I. Frecot· 4 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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10 shared papersBiochemistry

U. Rothbauer

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Nanobodies as novel tools to monitor the mitochondrial fission factor Drp1

T. Froehlich, A. Jenner, C. Cavarischia-Rega, F. O. Fagbadebo, Y. Lurz, D. I. Frecot, P. D. Kaiser, S. Nueske, A. Scholz, E. Schaeffer, A. J. Garcia-Saez, B. Macek, U. Rothbauer

This study develops nanobodies to monitor Drp1, a mitochondrial fission factor, using proteomics, microscopy, and live-cell imaging techniques to study its dynamics in disease models.

bioRxiv · Dec 18, 2023 · PreprintCell Biology

Development of a PNGase Rc column for online deglycosylation of complex glycoproteins during HDX-MS

T. O. T. Lambert, M. Gramlich, L. S. Stutzke, L. Smith, D. Deng, P. D. Kaiser, U. Rothbauer, J. L. Benesch, C. Wagner, M. Koenig, P. Pompach, P. Novak, A. Zeck, K. D. Rand

The paper develops a PNGase Rc column for online deglycosylation during HDX-MS, enabling efficient analysis of glycoproteins and mapping of mAb binding epitopes.

bioRxiv · Jul 28, 2023Biochemistry

Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells

T. R. Wagner, S. Blaess, I. Leske, D. I. Frecot, M. Gramlich, B. Traenkle, P. D. Kaiser, D. Seyfried, S. Maier, A. Rezza, F. Sonego, K. Thiam, S. Pezzana, A. Zeck, C. Gouttefangeas, , U. Rothbauer

This study develops human SIRPα nanobodies for both functional modulation of myeloid cells and in vivo imaging of tumor infiltration.

bioRxiv · Jun 27, 2023Immunology

A novel PNGase Rc for improved protein N-deglycosylation in bioanalytics and HDX-MS epitope mapping under challenging conditions

M. Gramlich, S. Maier, P. D. Kaiser, B. Traenkle, T. R. Wagner, J. Voglmeir, D. Stoll, U. Rothbauer, A. Zeck

bioRxiv · Apr 13, 2022 · PreprintBiochemistry

Monitoring extracellular ion and metabolite dynamics with recombinant nanobody-fused biosensors

S. Burgstaller, T. R. Wagner, H. Bischof, S. Bueckle, A. Padamsey, D. I. Frecot, P. D. Kaiser, D. Skrabak, R. Malli, R. Lukowski, U. Rothbauer

This study develops recombinant nanobody-fused biosensors to monitor extracellular K+, pH, and glucose in real time, demonstrating their utility in cancer and neuronal cells.

bioRxiv · Apr 12, 2022Biochemistry

A nanobody-based toolset to monitor and modify the mitochondrial GTPase Miro1

F. O. Fagbadebo, P. D. Kaiser, K. Zittlau, N. Bartlick, T. R. Wagner, T. Froehlich, G. Jarjour, S. Nueske, A. Scholz, B. Traenkle, B. Macek, U. Rothbauer

This study develops Miro1-specific nanobodies as tools for monitoring and modifying Miro1 function in cells, with applications in imaging and targeted degradation.

bioRxiv · Dec 10, 2021Cell Biology

A broadly neutralizing biparatopic Nanobody protects mice from lethal challenge with SARS-CoV-2 variants of concern

T. R. Wagner, D. Schnepf, J. Beer, K. Klingel, N. Ruetalo, P. D. Kaiser, D. Junker, M. Sauter, B. Traenkle, D. I. Frecot, M. Becker, N. Schneiderhan-Marra, A. Ohnemus, M. Schwemmle, M. Schindler, U. Rothbauer

This study identifies a biparatopic nanobody that protects mice from lethal SARS-CoV-2 infection and reduces viral load and inflammation.

bioRxiv · Aug 8, 2021 · PreprintBiochemistry

Single-domain antibodies for targeting, detection and in vivo imaging of human CD4+ cells

B. Traenkle, P. D. Kaiser, S. Pezzana, J. Richardson, M. Gramlich, T. R. Wagner, D. Seyfried, M. Weldle, S. Holz, Y. Parfyonova, M. Schaller, S. Nueske, A. Scholz, A. Zeck, M. Jakobi, , U. Rothbauer

This study develops single-domain antibodies to target and image human CD4+ cells in vivo, demonstrating their utility in immunotherapy monitoring.

bioRxiv · Jul 2, 2021Immunology

NeutrobodyPlex - Nanobodies to monitor a SARS-CoV-2 neutralizing immune response

T. R. Wagner, P. D. Kaiser, M. Gramlich, E. Ostertag, N. Ruetalo, D. Junker, J. Haering, B. Traenkle, M. Becker, A. Dulovic, H. Schweizer, S. Nueske, A. Scholz, A. Zeck, K. Schenke-Layland, , U. Rothbauer

The paper develops NeutrobodyPlex, a multiplex assay using bivalent nanobodies to analyze neutralizing antibodies against SARS-CoV-2 in patient sera.

bioRxiv · Sep 22, 2020 · PreprintImmunology

A novel epitope tagging system to visualize and monitor antigens in live cells with chromobodies

B. Traenkle, S. Segan, P. D. Kaiser, U. Rothbauer

This paper introduces a PepTag/PepCB system for real-time visualization and quantification of antigens in live cells using fluorescently labeled chromobodies.

bioRxiv · Jun 8, 2020Cell Biology