K. Schenke-Layland

Targeting of MMP-13 prevents aortic aneurysm formation in Marfan mice

This study shows that targeting MMP-13 prevents aortic aneurysm formation in Marfan mice by reducing collagen degradation and BMP activity.

Protein profiling of breast carcinomas reveals expression of immune-suppressive factors and signatures relevant to patient outcome

The paper profiles proteins in breast carcinomas to identify immune-suppressive factors and signatures linked to patient outcomes.

A platform of patient-derived microtumors identifies therapeutic vulnerabilities in ovarian cancer.

This paper develops a 3D patient-derived microtumor platform to identify therapeutic vulnerabilities in ovarian cancer by testing drug responses and immune cell interactions.

Inflammatory and regenerative processes in bioresorbable synthetic pulmonary valves up to 2 years in sheep: Spatiotemporal insights augmented by Raman microspectroscopy

This study uses histology, immunohistochemistry, and Raman microspectroscopy to analyze inflammatory and regenerative processes in bioresorbable pulmonary valves in sheep over 24 months.

Autologous human immunocompetent white adipose tissue-on-chip

This paper introduces a human-based, immunocompetent WAT-on-chip model that recapitulates adipose tissue heterogeneity and functions for metabolic research and personalized medicine.

FH loss in RPE cells causes retinal degeneration in a human RPE-porcine retinal explant co-culture model

This study shows that loss of FH in RPE cells causes retinal degeneration in a co-culture model with porcine retinal explants, with rod cells being the first to degenerate.

Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes

This study develops and tests human embryonic stem cell-derived chondrocytes for long-term repair of porcine articular cartilage, showing improved functionality compared to current methods.

NeutrobodyPlex - Nanobodies to monitor a SARS-CoV-2 neutralizing immune response

The paper develops NeutrobodyPlex, a multiplex assay using bivalent nanobodies to analyze neutralizing antibodies against SARS-CoV-2 in patient sera.

Extracellular Ca2+-sensitive fluorescent protein biosensor based on a collagen-binding domain

The paper introduces a Ca2+ biosensor based on a fluorescent protein fused with collagen-binding domains, demonstrating its use in 3D tissue models and FLIM microscopy.

WAT’s up!? – Organ-on-a-chip integrating human mature white adipose tissues for mechanistic research and pharmaceutical applications

The paper develops a WAT-on-a-chip system to study human white adipose tissue function and drug responses in obesity and diabetes.

Human Retina-on-a-Chip: Merging Organoid and Organ-on-a-Chip Technology to Generate Complex Multi-Layer Tissue Models

This study develops a retina-on-a-chip model using hiPSC-derived retinal cells to recapitulate retinal interactions and test drug effects.