Author

J. Keck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Evolutionary Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:Arabidopsis· 2 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. Weigel· 2 shared K. Dubiel· 2 shared M. Exposito-Alonso· 2 shared U. Lutz· 2 shared A. C. Barragan· 1 shared A. K. Simons· 1 shared A. M. van Oijen· 1 shared A. Robinson· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersEvolutionary Biology

D. Weigel

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Author profile →

5 papers

Recent·Most cited

Selection constraints of plant adaptation can be relaxed by gene editing

M. R. Ruffley, U. Lutz, L. Levanthal, S. Hateley, W. Yuan, J. Keck, S. Y. Rhee, D. Weigel, M. Exposito-Alonso

This study shows that gene editing can relax selection constraints on plant traits by altering genetic correlations between flowering time and water use efficiency in Arabidopsis thaliana.

bioRxiv · Oct 16, 2023 · PreprintEvolutionary Biology

Spatiotemporal dynamics of single-stranded DNA intermediates in Escherichia coli

M. E. Cherry, K. Dubiel, C. Henry, E. A. Wood, S. A. Revitt-Mills, J. Keck, M. M. Cox, A. M. van Oijen, H. Ghodke, A. Robinson

The paper uses fluorescence microscopy to study the spatiotemporal dynamics of single-stranded DNA in live E. coli cells, revealing patterns associated with DNA repair and replication.

bioRxiv · May 8, 2023 · PreprintBiophysics

A Genomically and Clinically Annotated Patient Derived Xenograft (PDX) Resource for Preclinical Research in Non-Small Cell Lung Cancer

X. Y. Woo, A. Srivastava, P. C. Mack, J. H. Graber, B. J. Sanderson, M. W. Lloyd, M. Chen, S. Domanskyi, R. Gandour-Edwards, R. A. Tsai, J. Keck, M. Cheng, M. Bundy, E. L. Jocoy, J. W. Riess, , C. J. Bult

The paper describes a collection of 79 genomically and clinically annotated lung cancer PDX models that retain patient tumor features and treatment responses, available through MMHCdb.

bioRxiv · Mar 6, 2022Cancer Biology

Small proteins modulate ion channel-like ACD6 to regulate immunity in Arabidopsis thaliana

J. Chen, L. Li, J. Kim, B. Neuhaeuser, M. Wang, M. Thelen, R. Hilleary, Y. Chi, L. Wei, K. Venkataramani, M. Exposito-Alonso, C. Liu, J. Keck, A. C. Barragan, R. Schwab, , W. Zhu

The paper identifies two small proteins, MHA1 and MHA1L, that modulate ACD6 activity in Arabidopsis thaliana, affecting growth and defense trade-offs through calcium influx regulation.

bioRxiv · Jan 25, 2021 · PreprintPlant Biology

Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction

J. D. Wang, B. W. Anderson, K. Liu, C. Wolak, K. Dubiel, K. A. Satyshur, J. Keck

The paper identifies a conserved (p)ppGpp binding motif in HPRT across species, showing that ligand binding varies with dimer-dimer interactions that evolved to regulate purine homeostasis.

bioRxiv · Apr 28, 2019Biochemistry