Senescent human fibroblasts have increased FasL expression and impair the tumor immune response
Mónica Cruz-Barrera, Joshua Dulong, Georgio Mansour Nehmo, Anthony Sonn, Gaël Moquin‐Beaudry, Basma Benabdallah, Oanh Lê, Christian M. Beausejour
The paper shows senescent human fibroblasts increase FasL expression, leading to T and NK cell apoptosis and impaired tumor immune response in humanized models.
Frontiers in Immunology · Oct 27, 2025Peer-reviewedCancer Biology