Oanh Lê

Senescent fibroblasts interfere with the tumor immune response in humanized models by inducing neutrophil extracellular traps

This study shows senescent fibroblasts in humanized mouse models promote tumor progression by inducing neutrophil extracellular traps (NETs) that impair immune responses.

Senescent human fibroblasts have increased FasL expression and impair the tumor immune response

The paper shows senescent human fibroblasts increase FasL expression, leading to T and NK cell apoptosis and impaired tumor immune response in humanized models.